Clomiphene Citrate (Clomid) Powder

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Description

Clomid is the commonly referenced brand name for the drug Clomiphene citrate. It is not an anabolic steroid, but a prescription drug generally prescribed to women as a fertility aid. This is due to the fact that Clomiphene citrate shows a pronounced ability to stimulate ovulation. This is accomplished by blocking/minimizing the effects of estrogen in the body. To be more specific Clomid is chemically a synthetic estrogen with both agonist/antagonist properties, and is very similar in structure and action to Nolvadex. In certain target tissues it can block the ability of estrogen to bind with its corresponding receptor. Its clinical use is therefore to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which enhances the release of LH and FSH. This of course can help to induce ovulation.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist – the cofactor used in that tissue cannot bind and so the receptor remains inactive – and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.

Clomid Clomiphene Citrate Properties

Product Name Clomiphene Citrate
Brand Name Clomid
Appearance White Crystalline Powder
Sample Picture  
Molecular Structure  
CAS Number 911-45-5
Formula C26H28ClNO
Molar mass 598.10 g/mol
Biological Half-Life 5-7 days
Suitable for Elderly, Adult
Assay 99%Min
Certification GMP, HSE, ISO 9001, USP
Storage Ventilation Low Temperature Drying
Shelf Life 2 Years
Supply Ability Mass Stock

Clomid Clomiphene Citrate Applications

For women.
1.Stimulate ovulation in a woman who does not ovulate or who ovulates irregularly;
2.Perform a Clomiphene challenge test, which is sometimes used to evaluate a woman’s ovulation and egg quality (ovarian reserve). When given early in a woman’s menstrual cycle for 5 days, Clomiphene elevates a woman’s follicle-stimulating hormone (FSH) level. On the next day, an FSH blood level that has dropped back to normal is a sign of a normal ovarian reserve and ovulation. An elevated FSH is a sign of low ovarian reserve. Women who have a diminished ovarian reserve can use donor eggs, which greatly improves their chances of giving birth to a healthy child;
3.Stimulate the development of multiple eggs for use with assisted reproductive technology, such as in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT);
4.Regulate ovulation in a woman who ovulates irregularly and/or is going to have intrauterine insemination or artificial insemination.
For men.
Clomiphene may be used to treat low sperm counts (oligospermia). Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.

Clomid Clomiphene Citrate Treatment Success Rates

Of women who are anovulatory (unable to produce an egg each month), approximately 70% will ovulate when treated with Clomiphene; and conception rates consistent with a patient’s age should be achieved. Women less than 35 can achieve pregnancy rates of 20-25% per month as long as there are no other significant factors present. Older patients may not achieve these rates as their declining egg quality will become a factor. We stress that success rates are highly individual and depend on a number of factors. The best thing to do is have a thorough discussion with one’s RE physician to gain a better understanding of the likelihood of success with this or any treatment plan.
There are alternate fertility treatments for those who do not become pregnant with Clomiphene therapy. If 3-6 full Clomiphene cycles do not result in a pregnancy, other methods of ovulation induction can be recommended. For older patients, gonadotropins and intrauterine insemination may be recommended. For younger patients, in whom the risk of multiple gestations may be too high with gonadotropins and IUI, In Vitro Fertilization may be the next best step that will be recommended.

Clomid Clomiphene Citrate Cooking Recipes

Clomiphene Citrate(Version I),50mg/ml
Material Requested
1 gram of Clomiphene Citrate
1 beaker suitable for holding the volume of liquids
7.6ml of Glycerol
11.3ml of 190 Proof Grain Alcohol
Manufacturing Procedure
1.Mix powder and 190 Proof Alcohol in the beaker
2.Gently swirl or stir the contents of the beaker until the solution is clear

Clomiphene Citrate(Version II),50mg/ml
Material Requested
1 gram of Clomiphene Citrate
1 beaker suitable for holding the volume of liquids
8.4ml of PEG 600
10.5ml of 190 Proof Grain Alcohol
Manufacturing Procedure
1.Place a sufficient amount of water in a pan and place on the stove
2.Remove from heat when the water reaches boiling temperature
3.Place the powder and the PEG in the beaker
4.Immerse the beaker in the pan of water so that the water is level with the top of the contents of the beaker
5.Gently swirl or stir the contents of the beaker until the solution is clear (reheat the water if necessary)
6.Remove the beaker from the water
7.Allow the PEG to cool down
8.Slowly add the 190 Proof Alcohol to the mixture
9.Gently stir until fully mixed.