Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including , but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
Ibutamoren MK-677 Properties
|Code Names||MK-677, MK-0677, L-163,191|
|Molar mass||528.662 g/mol|
|Certification||GMP, ISO 9001|
|Package||Discreet Disguised Package or as Required|
|Delivery Time||Within 24h|
Ibutamoren MK-677 Benefits
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS (Growth Hormone Secretagogue) on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle. Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
How to Take Ibutamoren MK-677?
MK677 is very popular with those who don’t like injections because it has an oral bioavailability. This means it can be taken by mouth without causing any toxicity to the liver, or being metabolized too quickly by the body. MK677 is safe for women to take. Similar doses to men can be used, but due to the large amounts of growth hormone produced, starting with 10mg is recommended. However, because of its interaction with IGF-1, and the potential to increase cell division, you should take advice from a physician before taking it if you have a history of tumors, growths or cancer.
It’s also not been demonstrated as safe to take for pregnant or breastfeeding women. The most common doses of MK-677 range between 5-25mgs per day. In some cases, we’ve seen doses upwards of 50mgs per day, but these are few and far between, and didn’t result in exponential benefits above the recommended top-end dosage of 20-25mgs per day.
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