Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5. Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases. The most abundant PDE in the human corpus cavernosum is the cGMP specific phosphodiesterase type 5; therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.
Levitra Vardenafil Properties
|Molar mass||488.604 g/mol|
|Biological Half-Life||4–5 hours|
|Uses||Erectile Dysfunction Treatment|
|Certification||GMP, ISO 9001, USP, BP|
|Policy||Free Reship Policy|
Directions For Use Levitra Vardenafil
Before you take Vardenafil, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about the tablets and will provide you with a full list of the side-effects which you may experience from taking them.
Take Vardenafil exactly as your doctor tells you to. It is intended to be taken before sexual activity – it is NOT for continuous daily use. You should take one tablet 25-60 minutes before you plan to have sex, although it may still be effective up to 4-5 hours after taking the tablet. You can take the tablet either before or after food but, if you have just eaten a large or high-fat meal, it may take longer for it to work.
There are three strengths of Vardenafil tablets: 5 mg, 10 mg and 20 mg. It is likely that you will be given the 10 mg strength tablet to begin with, but this may be changed subsequently depending upon how you react. Each time you collect a prescription, check to make sure it contains the strength of tablet you are expecting.
If you have been given orodispersible tablets, place one tablet on your tongue and allow it to dissolve before you swallow. Do not take the tablet with anything to drink.
Do not take more than one dose of Vardenafil in any 24-hour period.
Levitra Vardenafil Dosage Details
For most individuals, the recommended dose of Vardenafil regular tablets is 10 mg per day taken 60 minutes before intercourse. If there is no response or side effects, the dose may be increased to 20 mg or, if there are side effects, it may be reduced to 5 mg.
Individuals 65 years of age or older should begin therapy with 5 mg.
Individuals who are taking medications that increase the blood levels of Vardenafil should start treatment with 2.5 to 5 mg of Vardenafil. (See drug interactions.)
Orally disintegrating tablets (ODT) are not interchangeable with regular Vardenafil tablets because they are better absorbed and produce higher blood levels than regular tablets. The recommended dosing when using ODT is one tablet 60 minutes before intercourse. Only one tablet should be used per day. It should be placed on the tongue until it disintegrates and should not be swallowed with water.
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